Recently, the team led by Prof. He Chuanglong from the College of Chemistry, Chemical Engineering and Biotechnology (CCEB) at DHU, based on their previous achievements (Adv. Funct. Mater., Bioact. Mater., Biomater. Sci., Chem. Eng. J., ACS Nano), has made a series of breakthrough in bone repair. The research result was published in ACS NanoentitledFlowerbed-Inspired Biomimetic Scaffold with Rapid Internal Tissue Infiltration and Vascularization Capacity for Bone Repair.The corresponding authors are Prof. He Chuanglong, Dr. WangJinwu, Chief Physician of Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, and Dr. Ma Xiaojun, Deputy Chief Physician of Shanghai General Hospital.The first author is Dr. Zhou Xiaojun from theCCEB, DHU.
(Schematic Diagram of Preparation of DMSNs/SrHA/PGP Scaffold
with Guided Bone Tissue Regeneration)
Inspired by the characteristics of a “flowerbed”, the research team combined 3D printing and electrostatic spinning technologies to construct a bioactive scaffold (DMSNs/SrHA/PGP) with a 3D printed scaffold as the framework and electrostatic spun nanofibers as the filler. In the study, a sequential release behavior of DMOG and Sr ions was achieved to promote angiogenesis and osteogenesis for timely vascularization and stable bone formation, thereby facilitating bone defect repair. In addition, rapid tissue infiltration and guided vascularized bone regeneration can be promoted while providing a promising strategy for constructing a bone microenvironment-matched biomimetic scaffold for bone regeneration.